CALL FOR PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis Metformin attenuates hyperoxia-induced lung injury in neonatal rats by reducing the inflammatory response
نویسندگان
چکیده
Xueyu Chen, Frans J. Walther, Rozemarijn M. A. Sengers, El Houari Laghmani, Asma Salam, Gert Folkerts, Tonio Pera, and Gerry T. M. Wagenaar Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, The Netherlands; Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles Medical Center, Torrance, California; Department of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands; and Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
منابع مشابه
Metformin attenuates hyperoxia-induced lung injury in neonatal rats by reducing the inflammatory response.
Because therapeutic options are lacking for bronchopulmonary dysplasia (BPD), there is an urgent medical need to discover novel targets/drugs to treat this neonatal chronic lung disease. Metformin, a drug commonly used to lower blood glucose in type 2 diabetes patients, may be a novel therapeutic option for BPD by reducing pulmonary inflammation and fibrosis and improving vascularization. We in...
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Objective(s):Therapies with high levels of oxygen are commonly used in the management of critical care. However, prolonged exposure to hyperoxia can cause acute lung injury. Although oxidative stress and inflammation are purported to play an important role in the pathogenesis of acute lung injury, the exact mechanisms are still less known in the hyperoxic acute lung injury (HALI). Materials ...
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Objective(s): Asiaticoside (AS) displays anti-inflammation, and anti-apoptosis effect, but the role of AS in hyperoxia-induced lung injury (HILI) treatment is undefined. Therefore, the aim of this study was to investigate the effects of AS on HILI on premature rats and alveolar type II (AEC II) cells.Materials and Methods: Sprague-Dawley...
متن کاملRetracted: Time course changes of oxidative stress and inflammation in hyperoxia-induced acute lung injury in rats
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CALL FOR PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis Animal models of bronchopulmonary dysplasia. The preterm and term rabbit models
D’Angio CT, Ryan RM. Animal models of bronchopulmonary dysplasia. The preterm and term rabbit models. Am J Physiol Lung Cell Mol Physiol 307: L959–L969, 2014. First published October 17, 2014; doi:10.1152/ajplung.00228.2014.—Bronchopulmonary dysplasia (BPD) is an important lung developmental pathophysiology that affects many premature infants each year. Newborn animal models employing both prem...
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